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Syk Inhibitor II (hydrochloride)

CAS No. 227449-73-2

Syk Inhibitor II (hydrochloride) ( —— )

Catalog No. M17447 CAS No. 227449-73-2

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 201 Get Quote
5MG 431 Get Quote
10MG 614 Get Quote
25MG 896 Get Quote
50MG 1197 Get Quote
100MG 1611 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Syk Inhibitor II (hydrochloride)
  • Note
    Research use only, not for human use.
  • Brief Description
    Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.
  • Description
    Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Syk; PKCε; PKCβII; ZAP-70; Btk; Itk
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    227449-73-2
  • Formula Weight
    413.22
  • Molecular Formula
    C14H17Cl2F3N6O
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    NCCNC1=NC(NC2=CC(C(F)(F)F)=CC=C2)=C(C(N)=O)C=N1.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hisamichi H, etal. Bioorganic & medicinal chemistry, 2005, 13(16): 4936-4951.
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