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Syk Inhibitor II (hydrochloride)
CAS No. 227449-73-2
Syk Inhibitor II (hydrochloride)( —— )
Catalog No. M17447 CAS No. 227449-73-2
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 201 | In Stock |
|
| 5MG | 431 | In Stock |
|
| 10MG | 614 | In Stock |
|
| 25MG | 896 | In Stock |
|
| 50MG | 1197 | In Stock |
|
| 100MG | 1611 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSyk Inhibitor II (hydrochloride)
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NoteResearch use only, not for human use.
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Brief DescriptionSpleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.
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DescriptionSpleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSyk| PKCε| PKCβII| ZAP-70| Btk| Itk
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number227449-73-2
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Formula Weight413.22
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Molecular FormulaC14H17Cl2F3N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESNCCNC1=NC(NC2=CC(C(F)(F)F)=CC=C2)=C(C(N)=O)C=N1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hisamichi H, etal. Bioorganic & medicinal chemistry, 2005, 13(16): 4936-4951.
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